The growing number of African immigrants in the United States highlights the need to better understand their cardiovascular health. This study examines the association between duration of stay and cardiovascular disease (CVD) risk factors, such as hypertension, obesity, diabetes, and physical inactivity, among African immigrants. Using data from the National Health Interview Survey (2007–2017), a quantitative cross-sectional analysis of 3,782 participants was conducted with multivariate logistic regression. Statistical significance was set at p < 0.05. Results show that African immigrants who have lived in the US for at least 10 years (52.9%) are older, more educated, have higher annual incomes (p < 0.001), and are more likely to have health insurance (p < 0.001) than those with shorter residency (47.1%). However, they also exhibit higher rates of key CVD risk factors. The study suggests that prolonged residency may contribute to increased CVD risk due to changes in lifestyle, such as dietary habits, reduced physical activity, and increased exposure to chronic disease risk factors. These findings highlight the importance of culturally tailored health interventions to address CVD risk in this population. Programs promoting heart-healthy behaviors, including improved nutrition, regular physical activity, and better access to preventive care, could mitigate these risks. By emphasizing the relationship between residency duration and cardiovascular health, this study offers valuable insights into the unique challenges faced by African immigrants and the need for targeted public health strategies.