Diet, as a part of the lifestyle changes, may have an important role in optimizing and reducing the risk of atherosclerotic cardiovascular disease (ASCVD)—including coronary artery disease, stroke, peripheral artery disease, and their complications. This effect is multifactorial, associated with the reduction of the blood pressure, inflammation, oxidative stress, optimizing diabetes and overweight, and obesity (however, with no effect on even a small increase of cholesterol). Thus, the available studies showed very promising results concerning the moderate coffee consumption and ASCVD and CVD, and all-cause mortality risk reduction. There are, however, some dietary rules with coffee we should always remember. It is particularly beneficial to choose unsweetened ground coffee without milk. Drinking too much coffee should be avoided (it is important to maintain the golden mean—2-4 cups of coffee a day). In patients with uncontrolled severe lipid disorders and people with a genetically determined slower rate of caffeine metabolism, it is recommended to limit the amount of coffee consumed. Finally, we cannot overestimate the role of coffee in this context, and should always remember that diet, including coffee consumption, is always an add-on to optimal intensive therapy in those very high-risk patients.