Coffee is a beverage with complex health implications. For most individuals, moderate consumption provides numerous benefits across cardiovascular health, metabolic regulation, liver protection, and longevity. However, individual variability necessitates personalized recommendations based on patient history and comorbidities. Up to 400 mg/day (1–4 cups per day) of caffeine is safe. However, the time interval between coffee consumption and certain medications should be taken into account to avoid interactions. Family physicians can guide patients toward safe and beneficial coffee consumption practices tailored to their specific needs. They play a critical role in educating patients about the health benefits of moderate coffee consumption while addressing potential risks. This article focuses on the role of the family doctor in educating the patient about the effects of caffeine on the cardiovascular system, disease prevention, and potential risks associated with excessive consumption. This article also highlights the potential interactions of coffee with commonly used medications in clinical practice.