Microwave safe plastics (MPFCs) have seen a sudden upsurge in every household along with the ever-increasing apprehensions encasing the latent health implications of microplastics (MPs). This review precisely explores the complex dynamics between plastics and food during microwave irradiation. The review is predominantly focusing intentional and unclaimed additions in the microwave safe plastics with the aim to study its interactions and consequences under microwave heating conditions. Aiming towards assessing the purpose and potential impacts of intentional additives like plasticizers, colorants, and modifiers on food safety along with non-intentionally added substances (NIAS), inclusive of monomers, residuals, impurities, and processing byproducts, questioning their migration into food during microwave heating. This review systematically examines existing research on the toxicity of microwave-heated plastics, specifically focusing on intentional and unintentional substances and the leaching of MPs into food post-microwaving. MPFC manufacturing requires the addition of polypropylene, polyethylene, and silicone along with various other toxic compounds which leaches harmful chemicals in the food. The safe in the microwave safe is just a metaphor used to keep it safe from melting upon heating. The analysis extends to the potential release of unclaimed toxic compounds, such as bisphenol A (BPA), phthalates, and other harmful substances, shedding light on the intricate chemical interactions between plastics and various food components leading to severe health implications. Prospective risks include endocrine disruption, carcinogenicity, and developmental effects emphasizing the need for a deeper understanding of the consequences of microwave-plastic interactions on human health. The review concludes with insights into evolving manufacturing practices and recommendations for future research directions, aiming to contribute to the development of better and safer alternatives that ensure innocuous food consumption.