Heavy metals’ existence in rice, originating from both anthropogenic and Geogenic sources, presents noteworthy health hazards. Arsenic is the primary heavy metal to be concerned about in this study that looks at the levels of contamination in rice. Naturally occurring arsenic seeps into rice through the soil and water. The type of rice and agricultural techniques used can affect the quantity of arsenic that builds up. Rice can absorb a significant quantity of arsenic from flooded fields during cultivation due to its high porosity, which poses health problems. Dosage-response correlations are utilized to study the acute and long-term health implications on humans of consuming rice polluted with heavy metals. A number of methods for reducing the risk of contamination are looked at, including phytoremediation, post-harvest treatments, and pre-harvest methods, in addition to the importance of legislative and regulatory acts. The discussion highlights the need of addressing heavy metal pollution in rice and outlines future research goals to enhance mitigation strategies and regulatory frameworks. In conclusion, it is vital to safeguard human health and the sustainability of rice production systems throughout the world through preventive actions and multidisciplinary work.