The paper presents a solution for establishing a universal, bi-directional real-time communication between the Digital and Real Twins in mechanical engineering. The exemplary set-up consists of a three-axis XYZ cross table, which was developed together with the Digital Twin Framework in a Model-based Systems Engineering (MBSE) environment, applying the RFLP V-model method and using Dassault Systèmes’ 3DExperience platform. The Real Twin is controlled by a standard industrial programmable logic controller (PLC). The communication is implemented using Modelica, Named Pipes, and the OPC UA protocol. The paper describes the design and implementation of the communication interface, the connections, and the communication modes. It also describes the performance, precisely the expected turnaround time (expectation value) for one axis value, which is 10 ms for the chosen reference communication loop. Furthermore, the paper describes the potential applications of the solution in industry and education and discusses future challenges and opportunities. The scientific project constitutes the evidence that it is feasible to establish a complete Digital Twin Framework in a complex MBSE environment and yet achieve high performance. It bridges the gap between the Real and Digital Twin in mechanical engineering.