Biofilm formation is a defining feature of many different clinical manifestations of candidiasis, as a majority of Candida species are fully capable of forming adherent cell populations. The high levels of mortality detected with Candida infections associated with a biofilm etiology make it imperative to develop new therapeutic options. Repurposing, finding new uses for old drugs, can significantly reduce the effort, time and money required in drug development, and these repositioning approaches are especially appealing in disease areas with high unmet needs and a scarcity of novel drug candidates, which is the case in the antifungal space. The availability of repurposing libraries has greatly facilitated repurposing studies by allowing the large-scale screening of hundreds to thousands of drugs in an efficient manner. Here, we present a comprehensive review of these efforts in the search for drugs with novel anti-biofilm activity against Candida species.