The study of accessible interactive design for colorblind children's picture books is a profound topic that aims to explore how to create a more inclusive and friendly reading environment for this special group through technological innovation. Combining the current development status of colorblind children's picture books at home and abroad, combining with the research theory of barrier-free design and the current problems of colorblind children's picture books, we use the color simulator to compare the color effects of normal people's perspective and colorblind children's perspective to select more suitable color combinations for colorblind children's picture books, and carry out a series of interaction design strategies by combining with the current intelligent technology. Through careful selection of color combinations, we ensure that colorblind children can clearly identify the main elements and background differences in picture books, so as to make up for the lack of color perception. Combined with the skillful use of shapes and patterns, the communication of visual information is further strengthened. In the optimization of interactive experience, the dual assistance of sound and touch is introduced. Multi-fusion intelligent recognition and assisted reading, through the combination of voice prompts and visual aids, the system can guide children to gradually understand the relationship between color and shape in the picture book, and then improve their color perception and shape recognition ability, in-depth discussion of the principles and strategies of the application of barrier-free interaction design in the creation of the picture book design should pay attention to the integration of emotion and experience, through a variety of sensory stimulation and interaction methods The design should focus on the integration of emotion and experience, through diversified sensory stimulation and interactive methods, to stimulate the reading interest of color blind children.