Gilles Deleuze (1925–1995) never ceased to problematize traditional conceptions of the human being and much of his work seems to presage trans- and posthumanisms in many crucial respects even if he does not refer to them explicitly. Drawing on the philosophy of Nietzsche[aut]Nietzsche, Friedrich, Deleuze, alongside the philosopher Felix Guattari[aut]Guattari, Felix, reimagined a more immanent form of philosophy and speculative anthropology based on “assemblages.” Bodies were “without organs” and through their actions and encounters, could create new frames for mapping and organizing nature’s chaos. Deleuze sought to emphasize the dynamic multiplicity of reality by calling for a refoundation of philosophy on the basis of a rhizomatic model: information would unfold through the production of “spontaneous judgments” or disjunctive syntheses that produce meaning. Bodies were mutable, plastic and in possession of an infinity of virtualities. The body, by combining itself with machines and computers, could challenge “common sense,” produce unfamiliar visions of reality, and create new worlds and modes of existence. Crucially, Deleuze envisioned the emergence of a more transcendent form of meta-computing, one that would help reconcile us with nature and the mankind of the future—or what he calls the “overmen.” Humanity would thereby be restored to its universal destiny. Deleuze therefore anticipated not only a new way of thinking and philosophizing, but also the non-human future of mankind.