Humans’ appreciation for “Mother Nature” can be seen in literary works such as Henry Thoreau’s poem Nature, but nature has faced challenges. Aside from the highlighted issues such as climate change, lesser known but equally critical to our survival are water, energy, and food shortages. These resources are traditionally managed separately in different places and sectors, which results in solving crises of one resource at the expense of others, exacerbating the natural conflicts and constraints on resources, increasing global inequality, and restricting the access of the “bottom billion” to essential fresh water and food supply. Recognizing that the three resources are intrinsically interwoven, the concept of the water-energy-food (WEF) nexus, proposed in 2011, was quickly recommended by leading scientists and international organizations as an effective governing approach. It serves as a foundation for the UN Sustainable Development Goals (SDGs) developed in 2015 and is linked to other issues such as climate, economic development, population growth, environmental risks and management, global governance inefficiencies, geopolitical conflicts, urbanization, and globalization. Effective ways to promote the WEF nexus to the public for awareness and support for the concept are urgently needed.