This study explored the factors influencing university students’ satisfaction with online learning, based on the Technology Acceptance Model (TAM). It investigated how factors such as perceived usefulness, ease of use, and attitudes contribute to students’ satisfaction, extending beyond the limitations of specific contexts like the COVID-19 pandemic. The study employed an online survey of university students and analyzes the data using Partial Least Squares Structural Equation Modeling (PLS-SEM) to examine relationships between key variables, including the mediating roles of perceived usefulness and ease of use. The results demonstrate that students’ attitudes significantly impact their satisfaction with online learning. Perceived usefulness and ease of use strongly shape these attitudes, indicating the importance of enhancing both technical and experiential aspects of online learning platforms. The study offers theoretical and practical recommendations for improving student satisfaction in online learning environments by addressing ease of use, usefulness, and other influencing factors.