The volume of mining operations near residential areas is currently increasing, as well as the unit capacity of transportation equipment and the amount of simultaneously blasted rocs. Accordingly, the importance of research aimed at developing energy-efficient methods of rock crushing and the search for safe ways of their intensification with the minimal harmful effects of large-scale blasts is increasing. The paper outlines methodological aspects, and some results of the research focused on reducing the seismic effect of blasting and the impact that various factors have on the crushing effect of different charge designs in industrial blasting in open pits and during trials on a test site. Dependences are obtained of the ground displacement rate in different zones of the blast in fractured and solid rocks. The paper discusses the results of studying the dependence of the rational degree of blast crushing and the specific consumption of explosives on the rock strength; the correlation between the average lump size and the width of the retaining wall, as well as the dependence of the total energy consumption of the drilling and blasting operations and rock excavation on the average size of the rock lump when mining coal deposits. Dependences of the fine fraction yield on the density of the used explosives, and the size of the radial gap between the charging chamber wall and the explosive with different energy saturation was obtained using the Smooth Particle Hydrodynamics Method. The research focuses on the influence of charges with different blast characteristics on the rock fragmentation kinetics as well as on the regularities in the damage localization under simultaneous impact of the physical stress and the blast energy of the industrial explosive charges and high-power explosive charges.