Clay-based building materials are promising solutions for contemporary construction with low environmental impact. New processes and mix designs are currently being developed to address increasing demand. Thus, 3D-printed clay-based building materials are at the intersection of technology and sustainability trends. However, the durability of clay-based materials remains an issue as they are very sensitive to water. Liquid water leads to the collapse of clay-based structures, and bio-stabilizer identification remains a challenge. In this paper, different stabilizers and application modes against liquid water were investigated for 3D-printed clay. Gels extracted from Aloe Vera and Opuntia Ficus are shown to delay water imbibition and collapse of clay structures under full immersion. A bio-stabilizer for clay-based structures has been developed to help create a water-resistant wall with a bio-sourced binder.