Fire resistance and the properties of structural materials under high-temperature conditions are crucial aspects in designing safe and durable buildings. Structural masonry, an essential component in civil construction, is not immune to the adverse effects of extreme heat, as evidenced in fire incidents and other situations involving intense flame exposure. Understanding how masonry responds to such conditions is vital to ensuring structural safety and, consequently, protecting human lives and property. This research aimed to investigate the safety of extruded, pressed, and fired ceramic blocks (BCEPQ) exposed to high temperatures and how these conditions affect their physical and mechanical properties. The study relied on both experimental and numerical analyses to identify alternatives and standards that enhance safety and prevent potential failures. The methodology involved the experimental analysis of masonry prisms subjected to temperatures of 30 ℃, and 600 ℃ for 30 min in industrial furnaces, followed by compression testing using a hydraulic press. The results showed that BCEPQ performed well under the tested conditions, withstanding compression loads and maintaining stability at elevated temperatures. These findings underscore the ceramic blocks’ efficacy and potential applications in scenarios requiring enhanced fire resistance and structural integrity.