Bamboo bio-concrete (BBC) consists of a cementitious matrix that binds together plant biomass particles as bio-aggregates. Bamboo imparts characteristics such as lightness, low thermal conductivity, and reduced carbon footprint to the material. However, since bamboo is a combustible material, it is crucial to understand its behavior in fire situations. Therefore, this work aims to evaluate the fire reaction properties of bamboo bio-concretes and assess post-fire residual uniaxial compressive strength. For this purpose, bio-concretes with 30%, 40%, and 50% bamboo bio-aggregates, in volume, were produced, with a matrix composed of Portland Cement V-ARI, Fly Ash, and Metakaolin in mass proportions of 40:30:30, respectively. The water-to-binder ratio used was 0.35, and 2% calcium chloride was added as a set accelerator. The fire reaction properties were evaluated using a Mass Loss Cone Calorimeter with a heat flux of 50 kW/m2. Experimental results indicated that the heat release rate and total mass loss increased as higher fractions of biomass were incorporated into the samples. For BBC 30, BBC 40, and BBC 50 samples, the peak heat release rate values were 12.7 kW/m2, 13.7 kW/m2 and 16.0 kW/m2, respectively. Based on the results, even with 50% biomass content, the bio-concretes are non-combustible materials and do not contribute to the development of a fire.