Steel staggered truss framing (SSTF) structures, with high load-carrying capacity and good economic benefits, have been adopted in low intensity areas. The traditional seismic design of SSTF structure is that plastic hinges appear at chords at the end of the Vierendeel to realize the ductility of the structure. However, this requires a high cost to strengthen the rest of the member and repair after earthquake. The seismic force of SSTF structure is transferred to the foundation by slabs, shear connectors, and trusses sequentially floor by floor. The shear connector plays a key role in the shear path, and transfers lateral seismic force from truss to slab. Therefore, suitable designed shear connectors behave as both seismic isolation and energy dissipation. Therefore, two finite element (FE) models were established and verified: one with the weld element to simulate the rigid shear connector (RSSTF), and the other with the translator element to simulate the flexible shear connector (FSSTF) with appropriate plastic properties. The results of time-history analysis in five earthquakes proved that FSSTF has less seismic response and seismic design requirements. The damage to the truss during earthquakes has significantly decreased, and the stress level of the truss components has decreased by more than half. The floor shear force was more distributed to the columns, resulting in an 11.9% increase in stress at the end of the columns, which will be considered in the design.