First Nations cultures are the oldest continuous cultures in the world and stretch back over 70,000 years. The way that research is conceptualised, applied, and used globally is an outcome of cultural practice for all peoples. As such, it stands to reason that First Nations Peoples are the oldest researchers in the world and have research methodologies that enabled us to develop intimate knowledge of how to care for Country and thrive through ice ages, mass extinction events, mega droughts, and invasion and colonisation. As part of this colonisation of Australia, First Nations people became objects of study within the application of racialised pseudo-science. Alongside this objectification, the many ways of Knowing, Being, and Doing that First Nations people undertook across the continent and adjacent islands were also severely suppressed and disrupted. This chapter explores the history and philosophy of western scientific method, and how the suppression of STEM by the Catholic Church in the Dark Ages prompted a specific Humanist response during the Renaissance and Enlightenment periods. It further considers how these ontological positions have created a context where distance between the observed and observer has been prioritised, and the negative impacts this has had on the practice of the scientific method. Finally, this chapter examines how these positions are at odds with First Nations conceptions of the scientific method that focus on relationships and relationality between the observer and the observed. Finally, the chapter also suggests ways forward in the academy for First Nations researchers and considers how we can begin to decolonise research to better include First Nations ways and support all research in all disciplines.