The interaction between a fuel droplet and a premixed laminar flame is investigated in this study using a multi-fluid Diffuse-Interface approach. The influence of two parameters on the reacting zone is examined: the equivalence ratio of the premixed laminar flame and the relative velocity between the droplet and the stabilized flame front. After validating the equation of state’s extension to temperature-dependent heat capacities, direct numerical simulations of droplet-flame interaction are performed. The results are qualitatively analyzed, revealing a significant influence of the operating conditions.