The development of space activities in Mexico has been characterized by a technological and scientific origin, with a transition to commercial activities, and faces challenges due to the lack of a complete national legal framework. Mexico’s space journey began in the 1960s, with notable milestones like the National Commission of Outer Space, the launch of its first satellite, Morelos I, and its first astronaut, in 1985. While Mexico ratified key international treaties, such as the Outer Space Treaty of 1967, it has not developed a specific national law to regulate space activities. The creation of the Mexican Space Agency (AEM) in 2010 was a crucial step in formalizing space efforts, but the absence of detailed regulations has limited the agency’s ability to fully govern space activities. This situation has led to gaps in addressing issues like private sector involvement, resources utilization and the capacity building ranging from technology, science, law and social space studies. The purpose of this work is to show the linked context of historical space activities milestones with their law and regulations, expose the challenges and provide important points that need to be addressed for the long-term realization of space activities in Mexico.