Nature-friendly waste disposal methods are attracting the attention of researchers and industrialists to avoid the huge damage that going to occur to the earth in the coming future. The researchers are striving to modernize the available conventional disposal methods or substances through mechanization and modeling to meet the current demand for global waste treatment approaches. Biochar (BC) is a nature compatible carbonized porous compound obtained from sustainable biomass via controlled thermal treatment. It is the most trending compound to treat solid and liquid wastes. Various studies already elaborated the BC active role in cleaning of chemical pollutants of contaminated soil and wastewater treatments. Hence, this chapter covers the disposal of pharmaceuticals by BC. As these pharmaceuticals are also the most prevailing water contaminants that can be discharged from industrial and domestic wastes. BC preparation from various biological sources, optimization of production conditions like temperature, time of exposure and pyrolysis, characterization, principal mechanism for removal of pharmaceuticals through BC, and key publications that pin the elimination of drug contaminants from water resources and biological fluids were summarized in this chapter. Finally, advanced BC compounds such as magnetic, nanoBC preparation, applications, integration of machine learning (ML), and artificial intelligence (AI) tools in BC-based waste water treatment were discussed.