A significant increase in the influence of intangible factors of production in the modern world on economic processes, their constant interaction with classical markets of production factors, and, accordingly, the need to develop a methodology for assessing their mutual influence – all this predetermined the purpose and objectives of the study. The contribution highlights some approaches to determining the reputational capital of a region, considers directions for identifying the basic components of a reputational economy. In addition, a toolkit is proposed for assessing the mutual influence of indicators of a region’s reputational economy and classical markets: labor, capital, commodity market, that allows us to identify the closeness of the relationship between the qualitative and quantitative indicators of classical markets and the reputational capital of a region. Based on the conclusions made, a methodology for quantitative assessment of this influence is proposed, which is characterized by simple and convenient application in the implementation of the state regulation of the regional economy. The study is based on the analysis of statistical data for a nine-year period of economic development of the Republic of Tatarstan and is highly representative. Based on the results of the conducted study, the influence of each of the considered qualitative and quantitative indicators of classical factor markets on the dynamics of investments in fixed capital of the region was established, which made it possible to substantiate and formulate measures of state influence on the corresponding functional areas of development of the regional socio-economic system.