This chapter explores the interactions and intimate relationships between humans and nonhumans in the Southern Reach and Borne series. Building on existing scholarship and considering the classic tropes of the New Weird alongside object-oriented ontology’s formulation of relationality, it argues that Jeff VanderMeer’s novels conceive of worlds as shaped by specific entities rather than as amalgams of continuous processes. At the same time, they liberate nonhumans from the confines of human experience and emphasise the mystery, fragility, and complexity of interrelation. This chapter investigates the deep relational history of humankind, uncovering how the Southern Reach and Borne series represent the primal interconnectedness as well as disconnectedness between humans and nonhumans, an idea often shunned by existing studies of these texts.