In contrast to the diagnosis of fracture-related infection (FRI), no comprehensive consensus is available regarding management of FRI. Most concepts regarding treatment strategies are derived from periprosthetic joint infections, which are also associated to biofilm, but decisions are complicated in FRI by the concomitant need for fracture stabilization. Treatment strategies can include fracture union (suppression until fracture union and subsequent removal of implants), infection eradication (segmental resection of the infected bone and reconstruction of the bony defect), addressing both (debridement and implant retention or exchange) or none (antibiotic suppression). In any case, management should include surgical debridement and irrigation, tissue sampling, fracture stabilization, dead space management, soft tissue coverage, and targeted antimicrobial therapy. Surgery should be performed as soon as possible on an optimized patient (early elective surgery). Multidisciplinary teams provide better outcomes. One- and two-stage approaches have similar results in published studies. Adequate debridement is crucial in the management of FRI and the best predictor of success. Stability is indispensable for a biomechanical environment favorable to both bone union and infection eradication. The strategy for dead space management is interrelated with that for stabilization and soft tissue coverage. When soft tissue coverage techniques are required, they are best performed early.