The importance of psychological interventions in psycho-oncology is well recognized and gaining ground following the fact that nearly a quarter of patients with chronic medical problems have clinically significant psychological symptoms. Interventions are designed to respond to a broader population of cancer survivors experiencing diverse consequences such as worsening quality of life, depression, chronic cancer, and long-term physical suffering. They target the impact of physical symptoms on intimate relationships and social recovery. The systemic approach targeting social and interpersonal relationships before and after diagnosis of neoplasia is a core component of group therapy. This article is combined with the psychoeducational approach so that an integrative approach is developed to unite informational and therapeutic components with active psychological support. The applied systemic psychoeducational approach provided accurate knowledge of the disease, stress management, problem-solving, and coping strategies to patients and their family systems and explored the psychological processes of adaptation following the trauma of neoplasia by bringing awareness to the patients and their family’s needs and supporting the recovery process. Albeit recent developments in group therapy, systemic group therapy for women facing breast cancer (BC) or other gynecological cancers is rare, while online is almost nonexistent. COVID-19 restrictions accelerated the evolution and led, as described in this chapter, to the transition of a systemic therapeutic group intervention from in-person to online and back. The chapter highlights and discusses the components of the online intervention integrating systemic and psychoeducational methodology and the therapist’s experience in both settings in Greece.