In the course of a rapidly changing world of work, the question arises as to how organizations should be managed successfully today and in the future so that they can achieve their goals and their employees can work happily and healthily at the same time. AI has a great influence on several issues in the workplace, especially for people with disabilities. The Disability Management and the Disability Manager can have a high influence on what has to be done and not to be done. Further, they can influence the review of the output and the dataset. AI and Disability Management can only be successful if both parameters are in a balanced relationship for the respective organization, the employer, and the employee. The latter is particularly essential for sustainable and long-term performance as well as work and productivity. In the course of the change in the labor market, described in the introduction of this book, these aspects represent a major challenge for the future of the working world. What is meant by AI solutions in early intervention and in occupational rehabilitation? What is the role of Disability Manager, and what are the responsibilities of teams and employees in an organization? The following illustration points out the main aspects of how to implement technology and digital solutions in disability aspects in general. It is a concentrate of an EU research project.