Emerging Contaminants (ECs) in water environments brings huge potential threat to human health and even ecosystems. However, traditional wastewater treatment plants can’t completely remove them through existing technologies, so developing a more efficient water purification technology was urgent. The activation of peroxymonosulfate (PMS) using heterogeneous Cobalt-based catalysts to generate reactive oxygen species (ROS) such as sulfate radicals (SO4·−) with high oxidation potential and selectivity has been proven to be an effective advanced oxidation processes (AOPs). The Cobalt-based porous materials derived from Metal-Organic-Frameworks (MOFs) have uniformly dispersed metal active sites and a large number of mesoporous structures, which have great potential advantages in enriching and oxidizing organic pollutants. In this study, 10-CoHNPC-1000 was successfully synthesized. Research has found that the 10-Co-NHPC-1000 material has excellent saturation adsorption capacity and degradation rate constant for SMX, which were 81.67 mg/g and 0.056 min−1, respectively. This study provides ideas for designing efficient integrated materials for adsorption and degradation.