Purpose: To reveal the structural changes of the fovea during ocular movements and specifically from the temporal gaze to nasal gaze. Methods: A prospective controlled study design. The right normal eye of healthy individuals was enrolled. SDOCT cube scans were conducted. The central fovea thickness (CFT) was chosen as the primary measurement. The measurements were obtained at primary positions and at the temporal and nasal gaze. Four CFT values were recorded: CFT temp at the temporal gaze with a vertex X1 distance, CFT nasal at the nasal gaze with a vertex X2 distance, CFT1 at the vertex X1 and the straightforward position and the CFT2 at the vertex X2 and the straightforward position. The absolute difference between the CFT temp-CFT nasal was compared with the absolute difference between CFT1-CFT2 at the straightforward position of every patient. In order to assess the measurements, the paired t-test was implemented. Results: Twenty patients were included. The absolute difference |CFT1-CFT2| ranged from 1 μm to 4 μm with mean value equal to 1.6 μm. The absolute difference |CFTtemp-CFTnasal| ranged from 1 μm to 10 μm with mean value equal to 5.8 μm. (p = 0.0013). Conclusions: CFT showed significant fluctuation from temporal to nasal gaze. The structural deformation of the macula during the ocular movements deserves more attention as it may participate in the embryonic development of the eye and in the pathogenesis of macular diseases.