The tannery process generates a lot of wastewater in almost every step, and different processes have different wastewater characteristics. Today, the limited available freshwater resources are exposed to a variety of organic pollutants (through industrial wastewaters and chemical fertilizers) that seriously threaten the natural ecosystem and human health. Thus, tannery wastewater must be treated before being released into the environment. Tannery wastewater treatment consists of several stages, including pre-treatment, primary, secondary, and tertiary treatments. While traditional treatment methods are available; however, they are not completely effective for treatment tannery wastewater. This is due to the presence of high concentrations of organic matter, heavy metals, and high levels of chemical oxygen demand (COD) and biological oxygen demand (BOD). Among the common wastewater treatments, advanced oxidation processes (AOPs) are methods used for problematic organic pollutants removal which are difficult to degrade by conventional processes. This process produces high concentration of hydroxyl radical (·OH), which as a strong oxidizer is able to oxidize the majority of organic compounds to CO2, water, and mineral acids. Combining different processes is a promising strategy for enhancing the efficiency of pollutant removal from water and wastewater. The integration of advanced oxidation processes (AOPs) with other treatment methods has shown improved performance. This chapter provides various treatment processes for tannery wastewater, with a focus on advanced oxidation processes (AOPs) and hybrid technologies. It also explores treatment strategies specifically designed for managing wastewater generated by the tannery industry.