Since the first appearance of additive manufacturing in the late 1980s, significant advancements have been made in this field. Additive manufacturing (AM), also known as 3D printing, has a wide range of applications, including the production of physical prototypes, functional components, and complex biological structures. In recent years, the spotlight has turned towards smart materials, which could change shape or properties in response to external stimuli, leading to the emergence of four-dimensional (4D) printing. This work explores the computational design, analysis, and experimental investigation of 4D printed airfoils made from PLA, a shape memory polymer (SMP). These airfoils can adapt their shape to meet varying aerodynamic conditions and then return to their original form. The study includes an in-depth examination of the potential use of these smart materials in aerospace applications, specifically in the context of sports vehicle aerodynamics. These adaptive airfoils’ performance and design were verified by a series of computer simulations using CFD software. Following the calculations, the airfoils were created experimentally using 3D printing technique called Fused Deposition Modeling (FDM). The experimental protocol used the Taguchi De-sign of Experiments (DoE) methodology to examine in detail how different printing factors affect the airfoils’ aerodynamic performance and shape memory behavior. To evaluate the viability and efficiency of employing 4D printed airfoils in practical applications, the experimental findings were compared with computer projections. This research demonstrates the potential for significant advancements in the design and functionality of aerodynamic components, paving the way for future innovations in adaptive aerospace structures.