A common nerve transfer to restore wrist extension following injury to the radial nerve is the flexor digitorum superficialis (FDS) branch of the median nerve to the extensor carpi radialis brevis (ECRB) nerve transfer. The goal of this surgery is to restore the ability to extend the wrist to place the hand in a position of grasp and to provide stabilization of the wrist while gripping. Postoperative therapy includes three phases based on the donor activation focused rehabilitation approach. Therapy progresses based on manual muscle strength of the recipient ECRB muscle using manual muscle testing (MMT). Trace muscle contractions may not be observed for up to 9 months following surgery, and it generally takes 12–18 months to achieve functional movement. The FDS-to-ECRB nerve transfer is often performed in conjunction with the FCR-to-PIN nerve transfer, which provides finger and thumb extension. Compared to tendon transfers, a benefit of this nerve transfer duo is the potential ability to simultaneously extend the wrist and fingers together.