The paper describes the principles of designing a robust tracking system to control aviation information and measuring devices operated on moving vehicles in difficult real operation conditions accompanied by parametrical and coordinate disturbances. Expressions describing the connections of input and output signal vectors are represented. The simulation results of the synthesized system are shown. A relevant task of creating robust tracking systems providing combined control of aviation information-measuring devices, considering external coordinate disturbances and measurement interference, is set and solved. A mathematical description is obtained for the integrated function estimating the quality of the developed system. It considers the system’s accuracy and robustness, and control expenses under conditions of internal parametric and external coordinate disturbances. An algorithm for designing robust tracking systems of the type under study is presented based on structural synthesis and the results of modeling a robust tracking system for measuring and observing units functioning on aircraft. The represented outcomes could be applied to instrumentation assigned for operation on moving vehicles of the wide class.