The paper is devoted to the topical problem of intensification of entrepreneurial activity in crisis conditions due to the formation of a strategic model of human resources development. The preconditions and problems of Ukraine’s economic development in the context of the military invasion and predicted its current trends for the postwar recovery period were identified. It was determined that the key resource in terms of minimizing funding is human resources, the strategic development of which could form an effective system of recovery of the economy. The main priority in the development of human resources in the context of the EU accession is the movement toward achieving the Sustainable Development Goals. The measures of the mechanism of strategic human resources development include socio-demographic, financial and economic, scientific and technological, medical and organizational, educational, professional, and organizational and physiological activities. The need for a strategically oriented approach, improving the financial support of social development, projects and programs, innovation, digitalization, development of social inclusion, overcoming the “digital divide” has been justified. The necessity of improving the legislative support of human resources development, labor market regulation, social relations has been highlighted. The need for state support for innovation, development of innovation-integrated structures and innovation ecosystems, introduction of smart-approach and smart-specializations while the process of human resources development in strategic perspective has been marked. In order to ensure and support the process of strategic human resources development, a model of monitoring procedures was defined to intensify the process of overcoming crises and restoring socio-economic well-being.