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The metallic nanoparticles currently hold attractive applications in the fields of biomedical-, environmental-, and electronics engineering. By leveraging various physicochemical properties of the nanoparticles, the toxic effects of nanoparticles can be balanced. Among these properties, the surface property plays an important role, where stability of the nanoparticles helps in maintaining the integrity, thereby influencing their various biological toxicities. In our present study, we have synthesized a novel nanosystem comprising epigallocatechin gallate (EGCG)-coated gold nanoparticles and silver nanoparticles (AuNPsEGCG and AgNPsEGCG), which is further engineered with isoniazid (INH), a frontline anti-TB drug, yielding AuNPsEGCG@INH and AgNPsEGCG@INH. These nanoparticles were targeted to counter tuberculosis and its associated co-morbidities and disseminations. It is imperative to test the stability of these nanoparticles to ensure its usage in various applications. Therefore, the stability was tested in varying-media conditions (bovine serum albumin and NaCl), pH (pH = 5.5 and pH = 8.4), composition (AuNPs and AgNPs), and surface functionalization (EGCG and INH). It was found that AuNPs bearing the EGCG@INH moieties in alkaline conditions in bovine serum albumin were more stable. This study becomes imperative data to study the release of drugs and used in environmental toxicity mitigation.

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Stability Assessment of Isoniazid and EGCG Functionalized Gold and Silver Nanoparticles in BSA and Salt Solutions of Varying pH

  • 会议论文

  • 发表日期：

    2025年

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  • S. Jayshree,
  • Adora G. Christina,
  • P. Sanjay Sardar,
  • R. Abhishek,
  • Akhela Umapathi

摘要

The metallic nanoparticles currently hold attractive applications in the fields of biomedical-, environmental-, and electronics engineering. By leveraging various physicochemical properties of the nanoparticles, the toxic effects of nanoparticles can be balanced. Among these properties, the surface property plays an important role, where stability of the nanoparticles helps in maintaining the integrity, thereby influencing their various biological toxicities. In our present study, we have synthesized a novel nanosystem comprising epigallocatechin gallate (EGCG)-coated gold nanoparticles and silver nanoparticles (AuNPsEGCG and AgNPsEGCG), which is further engineered with isoniazid (INH), a frontline anti-TB drug, yielding AuNPsEGCG@INH and AgNPsEGCG@INH. These nanoparticles were targeted to counter tuberculosis and its associated co-morbidities and disseminations. It is imperative to test the stability of these nanoparticles to ensure its usage in various applications. Therefore, the stability was tested in varying-media conditions (bovine serum albumin and NaCl), pH (pH = 5.5 and pH = 8.4), composition (AuNPs and AgNPs), and surface functionalization (EGCG and INH). It was found that AuNPs bearing the EGCG@INH moieties in alkaline conditions in bovine serum albumin were more stable. This study becomes imperative data to study the release of drugs and used in environmental toxicity mitigation.