The Chitteri hills in Tamil Nadu's Dharmapuri district, part of the Eastern Ghats, are renowned for their biodiversity and rich tradition of indigenous healing practices. Among its extensive flora, this study explores an abundance of oil-producing medicinal plants emphasizing their significance in the region's ethnomedicinal practices. This study utilized semi-structured interview with open-ended questions, engaging 15 informants to gather in-depth insights into oil-yielding medicinal plants. Additionally, the statistical Use Value (SUV) was calculated to quantify the versatility of each plant species. The research sheds light on 51 plant species belonging to 22 families. The most common family was Lamiaceae, with trees and shrubs comprising the predominant life-forms. Leaves were the most often used plant parts for oil extraction followed by seeds, bark, flowers, and fruits. A few species were under threat as per the IUCN list, stressing the requirement for protection needs. These medicinal plants encompass a wide range of medical applications, including infections, diabetes, respiratory difficulties, pain management, fertility, and cancer treatment. The study emphasizes the value of traditional knowledge in generating novel medicines for a variety of health concerns. The documentation of oil-yielding medicinal plants in the Chitteri hills provides unique insights into ethnomedicinal practices.