Piper betle L. (betel), known as golden heart-shaped leaves, is a plant of significant medicinal and cultural importance, particularly in South and Southeast Asia. The study aims to reveal the health practices, medicinal properties, and other uses among local people in Myanmar. We engaged with local communities, conducting in-depth interviews with 57 informants to gather sociodemographic data and insights into the medicinal, social, and cultural uses of this species. We also investigated the cultural and scientific research connections of betel among Asian countries through a literature review. The result found that betel plays an important role as a home remedy, formulated medicinal product and cultural belief use. It is widely applied not only in rural villages but also in urban areas for their primary health care . It is crucial to balance cultural habits with chewing practices, health, and religious beliefs in using betel by local people. Regulating the status of chewing practices is needed for policymakers. Both the health benefits and the risks of using betel should be further studied by taking traditional knowledge and local practices into account.