Tissue engineering has intriguingly presented the prospect of treating a wide range of medical conditions by growing new tissue. However, despite notable advancements in in vitro and preclinical research, there has been a slow pace in achieving clinical and commercial endpoints. Many contend that this is because of inaccurate scientific rationale, which could prevent the achievement of long-term objectives, particularly in managing the disease for which there are currently no effective conventional therapies. However, current methods may not allow for long-term and sustainable tissue engineering. One of the most important variables in this situation is the selection of the biomaterial, which serves as a “scaffold” to direct the regeneration process. Though, the need for biodegradability, biocompatibility, Bioresorbability, recycling and reuse must be prerequisite for the selection of material for the development of environmentally sustainable tissue engineering templates. Materials that are intended to have no physiological function that could encourage the targeted cells to regenerate new and relevant tissue(s), like many synthetic bioabsorbable polymers, are unlikely to be effective. Hence, tissue-engineering frameworks that are environmentally sustainable could be promising scaffold for future regenerative medicine.