Green biomaterials (GBs) are defined as materials derived from biodegradable, renewable, and environmental sources as eco-friendly implants. These emerging materials have great potential to withstand and achieve sustainable developments to enhance various healthcare and industrial applications. GBs have significant advantages over conventional materials as they are biocompatible, reduce environmental impact, and have the capability to replace petroleum-based materials. Plant-derived composites, microbial products, and bio-based polymers are GBs, presenting many opportunities for the world of GBs. Technological advancements in bio- and nano-engineering are providing the capability to create materials with enhanced functions and characteristics. The amalgam of green chemistry within the circular economy, further provides a sustainable lifecycle of products with enhanced recyclability and less waste. GBs in medical applications are providing promising solutions for preparing safe and quality implants, enhancing drug delivery systems, and creating tissue-engineered scaffolds for eco-friendly healthcare practices. In the present era of advanced GB research, this review was prepared with a critical view of GBs as it provides a platform to explore emerging GB applications with a focus on providing relevant cross-disciplinary research and policy initiatives to foster innovation and practical-based applications for clinical applications. In summary, this chapter highlights that GBs are truncating the growth of material science and biotechnology to significantly contribute to global sustainability goals while enhancing medicine.