Under the term smoking-related diseases several diseases with quite different morphological features are discussed, but all of them are related to cigarette smoke exposure, most often in young aged heavy smokers. Some present with interstitial fibrosis, others show granulomas centered on the airways, and others present with an inflammatory cell infiltration along the airways. Included are Langerhans cell histiocytosis, respiratory bronchiolitis-interstitial lung disease, desquamative interstitial pneumonia, smoking-related interstitial fibrosis, and chronic obstructive pulmonary disease. A short paragraph is added for lung injury induced by e-cigarette and shisha smoking, although our knowledge of these injuries is still limited.