This chapter explores the integration of AI in the biomedical field, emphasizing its synergy with digital technologies. It discusses digital medicine’s role in enhancing health services through connected devices, telemedicine, and decision-support algorithms. AI facilitates data analysis, enabling intelligent machines to replicate human-like intelligence in healthcare. Regulatory acceptance will be important for the economic viability of digital health solutions, with foreseen significant growth in the digital health market. Specifically, AI is set to transform healthcare by leveraging advancements in computational sciences, machine learning, and data availability. These technologies enable the creation of powerful predictive and prescriptive models, enhancing medical diagnosis, drug discovery, and patient care. AI applications in health include early disease detection, personalized medicine, and improved hospital management. The ongoing evolution of AI technologies, including self-learning and quantum computing, promises further advancements, potentially revolutionizing healthcare. The rise of autonomous AI systems may pose challenges in the future in maintaining human control and ethical considerations.