The integration of AI in health and other fields presents opportunities and challenges, emphasizing the need for synergy between human and artificial intelligence. The “centaur theory,” originating from the chess game, advocates for collaboration, leveraging human imagination and machine computing to enhance decision-making. While AI excels in specific tasks, human oversight ensures ethical applications. This partnership is crucial for future advancements, especially in medicine. Training professionals in AI and digital technologies is essential to harness these innovations effectively and ethically, avoiding the risk of AI overshadowing human expertise. This chapter discusses the necessity of establishing legal and ethical frameworks to guide AI development, drawing parallels with the successful regulation of biotechnologies. Lessons from biotechnologies illustrate the potential for balanced regulation that fosters innovation without compromising safety, highlighting the need for transparency, inclusivity, and regular updates to regulatory frameworks. It emphasizes the importance of international cooperation in setting shared ethical standards to ensure AI benefits humanity while mitigating risks. The European regulation for data protection (GDPR) as well as the recently implemented European AI Act represent the first regulatory frameworks to foster the responsible use of AI to the benefit of mankind.