This chapter explores the evolving perspectives on prolonging life and delaying aging through technological advancements. It delves into the philosophical and biological aspects of aging and death, emphasizing the transhumanist vision of overcoming mortality. Key figures like Ray Kurzweil advocate for using technology to extend life, possibly achieving “the death of death” by 2045. The text examines methods like cryonics and cloning, highlighting their current limitations. It also addresses the ethical considerations of assisted suicide and euthanasia, reflecting on the evolving societal attitudes toward end-of-life care. Significant challenges remain in understanding and manipulating the biological mechanisms of aging. Nonetheless, AI could support the emergence of an anti-aging medicine. This may involve a combination of behavioral changes, innovative treatments like stem cell regeneration, and pharmacological interventions targeting aging processes. AI could play a crucial role in identifying therapeutic targets and developing senolytic drugs to eliminate senescent cells. It could also aid in simulating long-term clinical studies with virtual patients, accelerating the evaluation of drug effectiveness. As the global population ages, with centenarians expected to reach 3.2 million by 2050, these advancements could significantly enhance the lifespan and quality of life, presenting both opportunities and societal challenges.