The integration of AI and advanced therapeutic modalities is transforming human enhancement, a concept central to transhumanism, a movement advocating the use of technologies to surpass natural human limits by enhancing physical and cognitive abilities. While sports performance has historically improved through various means, including doping, the future may see genetic and microbiome modifications. Similarly, drugs are used to enhance sexual performance and assist in gender transition. The pharmaceutical industry has recently developed innovative obesity treatments, with drugs based on GLP-1 analogs offering significant weight loss alternatives to surgery. AI also plays a crucial role in personalizing cosmetic applications, allowing for tailored approaches in esthetics and body transformation. Additionally, AI aids in the development of new drugs for neurodegenerative diseases, leveraging digital models to predict treatment efficacy. Interest grows in cognitive enhancement for healthy individuals, with nootropics and devices like electrostimulation gaining attention. Brain-computer interfaces and implants, explored by institutes and companies like Neuralink, aim to enhance brain functions. These developments blur the lines between humans and machines, raising ethical considerations about the alteration of human cognition and identity.