In the Industry 5.0 landscape, supply chains are evolving with a renewed focus on human involvement at the heart of technological progress. This chapter delves into the transition from Industry 4.0 to Industry 5.0, highlighting a shift toward human-centered strategies that enable seamless collaboration between people and machines prioritize customization and advance sustainability. It introduces the concept of smart supply chains, which leverage a blend of IoT, AI, blockchain, big data analytics, robotics, and cloud computing to improve adaptability, efficiency, and responsiveness. The chapter examines key technologies that enhance visibility, enable real-time monitoring, support predictive maintenance, and facilitate data-driven decision-making. It emphasizes the growing role of collaborative robots (Cobots), tailored solutions, and the need for workforce upskilling within this modern industrial framework. Sustainability takes center stage through discussions on circular economy practices, eco-friendly logistics, and energy-saving measures. Additionally, the chapter tackles challenges such as data security, integration of outdated systems, managing organizational change, and navigating regulatory requirements, offering actionable solutions for each. Case studies from sectors like automotive, retail, healthcare, and agriculture showcase the advantages of smart supply chains in the Industry 5.0 era. The chapter also looks ahead to emerging trends, including quantum computing, 5G, digital twins, and augmented reality (AR), giving readers a glimpse into the future of supply chain management. Ultimately, this chapter provides professionals with a well-rounded understanding of how Industry 5.0 principles can be applied to create smart, sustainable, and human-centered supply chains that drive business success and growth.