In recent years, research has shifted its attention toward artificial intelligence (AI) and its impact on the workplace. However, there is insufficient systematic review that summarizes the role of AI in facilitating a smooth transition within organizations as they navigate change, address challenges in maintaining a positive workplace culture, and define the role of leadership in a new environment where humans and AI coexist. Further research is needed to examine the ethical concerns, potential biases, and risks of relying more on technology, which may impact on employee engagement and productivity of organizations. This study aims to systematically review recent articles to explore the role of AI in assisting successful organizational change, managing a resilient work culture, and supporting effective leadership. The databases EBSCO-ERIC, ProQuest, and JSTOR were used to search eligible articles published with the query terms human resources, AI and organizational change, AI and organizational culture, leadership, and ethical AI practices. Articles from online news sources were also reviewed. A total of 79 articles were included in this study. The authors found that artificial intelligence and humans can co-manage the organizations by resolving a set of identified issues. Implementation of AI creates organizational change, which can be well-managed by effective leadership and dynamic organizational culture. Organizational change in turn has an impact on the organizational culture. There should be a more balanced human-AI centric approach while personalizing AI tools to align with organizational goals and values. Specific organizational cases are discussed to display the opportunities and pitfalls of applying AI. Recommendations are provided to establish ethical guidelines promoting inclusivity, fostering a culture of continuous learning for sustainable organizational growth while embracing change.