Gender transformative policies and practices address underlying gender inequities and respond to specific social, health, or economic problems. Gender transformative approaches have historically focused on improving women’s status by changing gendered power relations, redefining masculinities, and exhorting communities and institutions to address the drivers and root causes of problems. Sex and gender entanglement poses a challenge to making policies and practices that can better reflect gender transformative approaches in that such approaches need to be robust, precise, and based on evolving science. This chapter proposes expansions of theory and practice to progress gender transformative approaches that reflect both sex/gender entanglement and engage all gender groups in efforts to reduce gender inequity. Achieving these goals requires (re)committing to feminism, engaging as critically with femininities as masculinities, integrating corporeality, and recognizing individual and collective agency in responding to hegemonic gender. These actions need to recognize ongoing and evolving impacts of sex and gender and sex/gender entanglement. This approach will facilitate improvements in policy and support new areas of gender transformative practice that can be operationalized with more precision in a proportionate universalism framework that differentially attends to groups based on need and disadvantage. Examples of gender transformative policy approaches consider entanglements of sex/gender in regulatory, communication, and policy activities aimed at reducing gender inequity.