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Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with evidence suggesting that the gut microbiome plays a critical role in its pathogenesis. This study aims to explore the gut microbiome composition and diversity in 42 Thai patients, consisting of colorectal cancer (CCR) and normal subjects, using both fecal and tissue samples. This study also explores potential differences between polyp-associated microbiome and CRC to assess possible transitions in microbial communities. Samples were categorized into 6 CRC feces, 6 CRC tissue, 9 Polyp feces, 15 Normal feces, and 6 Normal tissue. Microbial diversity was evaluated using alpha and beta diversity metrics, and taxonomic composition was compared across groups. Our findings highlight increased microbial dispersion in CRC tissue compared to fecal samples, suggesting a more heterogeneous microbial landscape in cancerous tissues. Polyp feces exhibited intermediate microbial profiles, potentially reflecting a transitional state between healthy and cancerous conditions. Anti-inflammatory taxa such as Faecalibacterium prausnitzii and Akkermansia muciniphila were more prevalent in normal samples. However, the absence of age, sex, and clinical data limited our ability to interpret results in a broader clinical context. Additionally, the relatively small sample size, particularly in certain groups like CRC tissue and Polyp feces, may have influenced the statistical power of our findings. Despite these limitations, the observed differences in diversity and microbial composition between cancerous and non-cancerous samples, as well as the transitional state seen in Polyp feces, provide valuable insights into the potential role of the microbiome in colorectal cancer development. Future studies should aim to incorporate clinical metadata and larger, more diverse patient cohorts to better understand the microbiome's role in CRC progression, its potential as a biomarker for early detection, and its possible implications for personalized therapeutic strategies.

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Gut Microbiome in Colorectal Cancer: A Bioinformatic Analysis of the Microbial Metagenome

  • 会议论文

  • 发表日期：

    2025年

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  • Jbara Soumaya,
  • Zainab El Ouafi,
  • Laila Ouafiq,
  • Sara Ouled Saber,
  • Sara Fadel,
  • Najib Al Idrissi,
  • Wajih Rhalem,
  • Rajaa Tissir,
  • Ghazal Hassan

摘要

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with evidence suggesting that the gut microbiome plays a critical role in its pathogenesis. This study aims to explore the gut microbiome composition and diversity in 42 Thai patients, consisting of colorectal cancer (CCR) and normal subjects, using both fecal and tissue samples. This study also explores potential differences between polyp-associated microbiome and CRC to assess possible transitions in microbial communities. Samples were categorized into 6 CRC feces, 6 CRC tissue, 9 Polyp feces, 15 Normal feces, and 6 Normal tissue. Microbial diversity was evaluated using alpha and beta diversity metrics, and taxonomic composition was compared across groups. Our findings highlight increased microbial dispersion in CRC tissue compared to fecal samples, suggesting a more heterogeneous microbial landscape in cancerous tissues. Polyp feces exhibited intermediate microbial profiles, potentially reflecting a transitional state between healthy and cancerous conditions. Anti-inflammatory taxa such as Faecalibacterium prausnitzii and Akkermansia muciniphila were more prevalent in normal samples. However, the absence of age, sex, and clinical data limited our ability to interpret results in a broader clinical context. Additionally, the relatively small sample size, particularly in certain groups like CRC tissue and Polyp feces, may have influenced the statistical power of our findings. Despite these limitations, the observed differences in diversity and microbial composition between cancerous and non-cancerous samples, as well as the transitional state seen in Polyp feces, provide valuable insights into the potential role of the microbiome in colorectal cancer development. Future studies should aim to incorporate clinical metadata and larger, more diverse patient cohorts to better understand the microbiome's role in CRC progression, its potential as a biomarker for early detection, and its possible implications for personalized therapeutic strategies.