As companies face the unique challenges of the Anthropocene era, the integration of spirituality into corporate sustainability practices emerges as a transformative approach. This study offers a comprehensive literature review to examine how spiritual principles can enhance sustainability within corporate settings. The objective is to assess the influence of spirituality on business strategies and practices, employee well-being, and stakeholder relationships. Using a systematic ten-step methodology, we identified and analysed the most relevant scientific literature up to 2023 on both spirituality and sustainability, categorizing the findings into eight thematic clusters: spiritual leadership and ethical practices; spirituality in management education and corporate social responsibility; ethical leadership and organizational values; spirituality and consumer behaviour in healthcare and tourism; spirituality in organizational development and cultural integration; spiritual leadership and workplace spirituality; spiritual capital and community well-being; and spiritual leadership in organizational change and employee well-being. The contributions within each cluster were examined, uncovering key insights and highlighting unresolved questions. Consequently, a research agenda is proposed to guide future studies on the mechanisms through which spirituality promotes sustainable business practices.