The Homo EconomicusHomo economicus model serves as the ideology underlying of today’s mainstream business. This model represents and promotes materialistic egoism, according to which people and organizations only care about their own material benefit. Corporations focus on financial wealth creation. In doing so, they appropriate value from common natural and societal resources without paying the full price and externalize most of the costs upon society, nature, and future generations. Responding to the thus-created environmental and social ills, society demands more growth and money, which fuels corporate misfunctioning. The paper puts forward a spiritually informed “Enlightened Homo EconomicusEnlightened Homo Economicus” model in which it is understood that people are inherently related to nature, other people, and the transcendence. They have intrinsic motivation to act and consider both the material and the nonmaterial outcomes of their actions. The paper presents innovative companies that use the spiritually informed conception of humanity in their functioning. The paper concludes that to prepare future business leaders for tackling the messy, wicked problems of the Anthropocene era, the curricula employed in economics and business education should be broadened and refocused.