Utilization of paper as a platform for modern electronics opens new ways to form customizable, biodegradable, flexible, and inexpensive electronic systems. In turn, the processing of such substrates, taking into account their characteristics (wettability, roughness, chemical, and thermal stability) along with patterning structures of different compositions and geometries on their surfaces, requires novel approaches to the design of flexible/stretchable electronic components, circuits, and smart devices for functional sensing, health monitoring, and energy harvesting. This chapter will discuss the possibilities and perspectives of using hand writing as well as automated approaches—robot writing, direct laser writing, and 3D direct ink writing—in the context of the development and prototyping of paper-based devices. Particular attention is paid to evaluating the capabilities of various writing instruments as well as the types of functional inks compatible with them. Successful examples of pattering carbon and polymer structures on paper using direct laser writing are presented. The advantages and limitations of direct writing approaches for paper substrates are highlighted.