Alzheimer’s disease (AD) is a neurodegenerative disorder associated with the accumulation of amyloid-beta protein and the formation of neurofibrillary tangles due to hyperphosphorylation of tau protein. Due to the significantly increased number of AD patients across the globe, it is a matter of global concern and needs urgent action. It has been demonstrated that aging and epigenetic changes such as histone modification, chromatin remodeling, DNA methylation, etc. play a crucial role in the onset of neurodegenerative diseases including AD. Further, with increased age, there is a decline in physical/mental activities, increased oxidative stress, altered mitochondrial dynamics, several biochemical changes, and epigenetic modifications that add up the AD and related pathologies. Further, it has been shown that understanding the epigenetic regulation in aging and aging-associated neurodegenerative diseases might help us understand the details of disease mechanisms and discover the potential therapeutic targets for AD. In the current review, we have provided an update on Alzheimer’s disease and its link to aging and epigenetic modification.